Population Pharmacokinetic and Pharmacodynamic Modeling

As we acquire experience with the clinical and pharmacokinetic behavior of a drug, it is very desirable to capture this experience and its related information in the form of a population pharmacokinetic model, and then to relate the behavior of the model to the clinical effects of the drug or to a linked pharmacodynamic model. The purpose of population modeling is thus to describe and capture our experience with the behavior of a drug in a certain group or population of patients or subjects in a manner that will be useful for the treatment of future patients. This is true not only for clinical patient care, but also to optimize each step of drug development, to develop the optimal understanding of drug behavior, so that the next step can be taken most intelligently.